Modulation of Beta oscillations in the subthalamic nucleus with prosaccades and antisaccades in Parkinson's disease.
Identifieur interne : 000D28 ( Main/Exploration ); précédent : 000D27; suivant : 000D29Modulation of Beta oscillations in the subthalamic nucleus with prosaccades and antisaccades in Parkinson's disease.
Auteurs : Akihiro Yugeta [Canada] ; William D. Hutchison ; Clement Hamani ; Utpal Saha ; Andres M. Lozano ; Mojgan Hodaie ; Elena Moro ; Bogdan Neagu ; Robert ChenSource :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Beta Rhythm (physiology), Deep Brain Stimulation (methods), Electromyography, Electroretinography, Evoked Potentials (physiology), Female, Humans, Male, Middle Aged, Ocular Motility Disorders (etiology), Ocular Motility Disorders (therapy), Parkinson Disease (complications), Parkinson Disease (therapy), Reaction Time (physiology), Saccades, Subthalamic Nucleus (physiology).
- MESH :
- complications : Parkinson Disease.
- etiology : Ocular Motility Disorders.
- methods : Deep Brain Stimulation.
- physiology : Beta Rhythm, Evoked Potentials, Reaction Time, Subthalamic Nucleus.
- therapy : Ocular Motility Disorders, Parkinson Disease.
- Aged, Electromyography, Electroretinography, Female, Humans, Male, Middle Aged, Saccades.
Abstract
Increased oscillations in the beta band are thought to be related to motor symptoms of Parkinson's disease (PD). Previous studies have shown that beta-band desynchronization in the subthalamic nucleus (STN) is reduced just before and during limb movements. While the STN is part of the basal ganglia (BG)-thalamocortical circuit controlling limb movements, it is also part of the BG-brainstem projection controlling saccadic eye movements. Late-stage PD patients have deficits in saccades in addition to difficulties with limb movements arising from impaired functions of the BG. We investigated saccade-related changes in beta-band (15-30 Hz) oscillatory activities in the human STN while PD patients performed visually guided prosaccades and antisaccades, the latter requiring suppression of reflexive responses and volitional initiation of saccades. We recorded local field potentials from deep brain stimulation electrodes implanted in the STN in human PD patients 1-5 d after surgery and compared prosaccades and antisaccades with these and with limb movements. Saccade-related beta-band desynchronizations were observed just before and during saccades in all subjects, suggesting that reduction of beta-band oscillatory activity in the STN is related to preparation and execution of saccades. Furthermore, beta-band desynchronizations for antisaccades started earlier, were sustained for longer periods, were of greater magnitude, and were observed more often than prosaccades. Beta-band desynchronization in the STN may reflect the additional processes associated with suppression of reflexive responses and volitional execution of saccades in the opposite direction.
DOI: 10.1523/JNEUROSCI.2564-12.2013
PubMed: 23595748
Affiliations:
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Hutchison</name></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name></author><author><name sortKey="Saha, Utpal" sort="Saha, Utpal" uniqKey="Saha U" first="Utpal" last="Saha">Utpal Saha</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Neagu, Bogdan" sort="Neagu, Bogdan" uniqKey="Neagu B" first="Bogdan" last="Neagu">Bogdan Neagu</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="eISSN">1529-2401</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Beta Rhythm (physiology)</term><term>Deep Brain Stimulation (methods)</term><term>Electromyography</term><term>Electroretinography</term><term>Evoked Potentials (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Ocular Motility Disorders (etiology)</term><term>Ocular Motility Disorders (therapy)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Reaction Time (physiology)</term><term>Saccades</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Ocular Motility Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Beta Rhythm</term><term>Evoked Potentials</term><term>Reaction Time</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Ocular Motility Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Electromyography</term><term>Electroretinography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Saccades</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Increased oscillations in the beta band are thought to be related to motor symptoms of Parkinson's disease (PD). Previous studies have shown that beta-band desynchronization in the subthalamic nucleus (STN) is reduced just before and during limb movements. While the STN is part of the basal ganglia (BG)-thalamocortical circuit controlling limb movements, it is also part of the BG-brainstem projection controlling saccadic eye movements. Late-stage PD patients have deficits in saccades in addition to difficulties with limb movements arising from impaired functions of the BG. We investigated saccade-related changes in beta-band (15-30 Hz) oscillatory activities in the human STN while PD patients performed visually guided prosaccades and antisaccades, the latter requiring suppression of reflexive responses and volitional initiation of saccades. We recorded local field potentials from deep brain stimulation electrodes implanted in the STN in human PD patients 1-5 d after surgery and compared prosaccades and antisaccades with these and with limb movements. Saccade-related beta-band desynchronizations were observed just before and during saccades in all subjects, suggesting that reduction of beta-band oscillatory activity in the STN is related to preparation and execution of saccades. Furthermore, beta-band desynchronizations for antisaccades started earlier, were sustained for longer periods, were of greater magnitude, and were observed more often than prosaccades. Beta-band desynchronization in the STN may reflect the additional processes associated with suppression of reflexive responses and volitional execution of saccades in the opposite direction.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Neagu, Bogdan" sort="Neagu, Bogdan" uniqKey="Neagu B" first="Bogdan" last="Neagu">Bogdan Neagu</name><name sortKey="Saha, Utpal" sort="Saha, Utpal" uniqKey="Saha U" first="Utpal" last="Saha">Utpal Saha</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Yugeta, Akihiro" sort="Yugeta, Akihiro" uniqKey="Yugeta A" first="Akihiro" last="Yugeta">Akihiro Yugeta</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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